.Wav being altered when copied over USB-mode

I experience that the files I have attached sounds very altered, when I copy them to S2400 over USB-mode.

Any suggestions or ideas why?

This is a 44.1Khz sample which will be resampled to 48Khz which will cause at least some aliasing when played on the 2400. If you have the ability to resample to 48Khz on your computer(e.g. wavelab, Audacity, Sound Forge, etc) using a higher quality algorithm you should be able to get a cleaner sound.