Never had any problems or hear any difference in my 2400 or overall sound. Unless you’re producing a comeback album for Michael Jackson or Prince, but unfortunately they both passed away.
16-bit 44/48 is sufficient. A lot of folks out there blabbering about these numbers like “I only produce in 96khz or 192khz” can’t put together a decent track with a gun to their head.
The only reason to convert to 48, is to save CPU cycles. It is very easy to max out the CPU when using 44.1 and then combining that with a busy sequence and/or loads of slices and/or a lot of simultaneous tracks. When passing the red line, samples are dropped, samples are glitching out, or the groove gets lost. Just straight up facts, at least with the current OS.