[Bug] S2400 USB Bricks Mac Pro Bluetooth

I have a weird one that I’ve gotten hints of in the past but I finally sat down and debugged:

If the S2400 is plugged into my computer via USB-B, the bluetooth on my Mac Pro crashes rendering my wireless mouse and keyboard dead.
I’ve tried a variety of USB-B cables with the same results. I have a bunch of other USB hardware plugged into my computer and it’s never had a problem. It’s only when I plug in the S2400 that the bluetooth goes haywire.

The computer is a 2019 Mac Pro with hella cores and RAM and everything is up to date with the latest drivers and such.

In the past, I’ve noticed that I can have >10 USB MIDI devices plugged into my computer in sync and shooting midi around like champs. When I turn on the S2400, everything gets out of sync or even just stops.

I don’t have access to a HW USB sniffer at the moment or I’d see what’s going on with the traffic between the S2400 and my computer.

Any suggestions for things to try?

Tried some more stuff this morning:

MIDI over USB B just seems borked. I can get Ito MSC mode over USB B. The unit still enumerates as a sound card and sends/receives audio over USB B from the computer.
I deleted the .set file to try to reinitialize the unit and the same thing keeps happening.

In Logic, I can see the S2400 and assign MIDI clock out to synchronize it, but the S2400 doesn’t receive the clock or start stop.
When I plug the S2400 into the USB host port on an iConnectivity Audio4c, MIDI works as expected and I can start/stop the unit and synchronize it.

Something fishy with the USB enumeration on the Mac.